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Istradefylline 40 mg/day increased peak concentrations and AUC of CYP3A4 substrates in scientific trials. This effect wasn't observed with istradefylline twenty mg/working day. Think about dose reduction of delicate CYP3A4 substrates.No particular dose adjustment suggested when tofacitinib coadministered with strong CYP2C19 inhibitors; lower tofaci
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